Evaluation and comparison of structurally different cellulose-based hemostatic agents in a rat kidney model

Different topical hemostatic materials are used to achieve effective hemostasis. High activity, biocompatibility, bioresorbability, and easy manipulation be expected in such a developed product. In the surgical world with these specific requirements, finding proper agent is very difficult. The study compared several of various construction properties, which were assessed for structural related properties by morphological analyses vivo their efficiency behaviour using model rat partial nephrectomy. New sodium salt carboxymethyl cellulose (CMC) sponge lowest porosity free swell absorptive capacity contained highest amount hydroxyl carboxyl groups. Results revealed that this CMC material form bioresorbable may ensure necessary effects, while also providing positive influence on reaction local tissue. needed significantly less time hemostasis (p < 0.001). Moreover, reached satisfactory results histopathological evaluation destruction score favorable healing reaction. This modified product proved itself promising hemostat, which, according its design, matches applications. general, obtained data elucidated dependency total effect structure composition.